Welcome to the personal page of Ching-Yu Chou
| Telephone | +33 169 08 86 20 |
| ching-yu.chou(at)cea.fr | |
| Office |
Bat 129 DSM / IRAMIS / SIS2M / LSDRM, CEA-Saclay 91191 Gif-sur-Yvette Cedex, FRANCE |
Field of research
- Relaxation methology --- hardware design and relaxation method development
- Field cycling relaxation --- methodology development of field dependent relaxation
- Protein dynamics investigation --- NMR relaxation and molecular dynamics simulation
Current research
Protein dynamics investigation by field dependent relaxation study:
Current molecular dynamics study can only be analyzed from simplified models and only investigate motion in certain time regimes. Using this field cycling technique one can investigate the CSA effect and obtain complete description of molecular motion. Characterization of molecular motion will not be restricted just to certain magnetic field, and dynamic parameters will be calculated much precisely without over model assumption.
I have designed and conducted a field-cycling device which has been assembled with a superconducting magnet and transport the sample to positions with desire magnetic fields in high and stable speed. Then I also conducted both theoretical and experiment studies to explore more avenues of field-dependent relaxation. Based on my studies, the molecular mobility can be precisely quantitatively described by the field dependent relaxation investigation. The hardware design has been published in JMR in 2012, January (see the publication list).
Current molecular dynamics study can only be analyzed from simplified models and only investigate motion in certain time regimes. Using this field cycling technique one can investigate the CSA effect and obtain complete description of molecular motion. Characterization of molecular motion will not be restricted just to certain magnetic field, and dynamic parameters will be calculated much precisely without over model assumption.
I have designed and conducted a field-cycling device which has been assembled with a superconducting magnet and transport the sample to positions with desire magnetic fields in high and stable speed. Then I also conducted both theoretical and experiment studies to explore more avenues of field-dependent relaxation. Based on my studies, the molecular mobility can be precisely quantitatively described by the field dependent relaxation investigation. The hardware design has been published in JMR in 2012, January (see the publication list).
Awards
- 2012, the Excellent Ph.D thesis Award, National Taiwan Normal University, Taiwan
- February 2012, the Excellent Poster Award, High-Field NMR Symposium in Materials and Biomedical Applications & Annual Meeting of Taiwan Magnetic Resonance Society in 2012
- May 2011, the Best Innovative Award, the 1st Prize of the 16th Biophysics Conference Poster Competition, Hualian, Taiwan
- May 2010, the Best Innovative Award, the 2nd Prize of the 15th Joint Biophysics Conference Poster Competition, Taipei, Taiwan
- 2008 fall semester, the Scholarship for the Best Graduated Student in National Taiwan Normal University, Taiwan
- 2005~2007 Scholarship of BioMedTec International Graduate School of Science - International Study Program Within the Elitenetzwerk Bayern, Germany
- June 2002, the award of the CHUNG-HSING Science at the National CHUNG-HSING University, Taiwan
- June 2002, the 2nd Prize in Physical Thesis Competition in the department of Physics, College of Science, CHUNG-HSING University, Taiwan
Publications :
- Ching-Yu Chou, Minglee Chu, Chi-Fon Chang and Tai-huang Huang
A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR
Journal of Magnetic Resonance, 214, 302-308 (2012) - Sue SC, Chang CF, Huang YT, Chou CY, Huang TH
Challenges in NMR-based structural genomics
Physica A - statistical mechanics and its applications 350 (1): 12-27. (2005)